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The OTUD6B-LIN28B-MYC axis determines the proliferative state in multiple myeloma.
Paulmann C, Spallek R, Karpiuk O, Heider M, Schäffer I, Zecha J, Klaeger S, Walzik M, Öllinger R, Engleitner T, Wirth M, Keller U, Krönke J, Rudelius M, Kossatz S, Rad R, Kuster B, Bassermann F. Paulmann C, et al. EMBO J. 2022 Oct 17;41(20):e110871. doi: 10.15252/embj.2022110871. Epub 2022 Sep 5. EMBO J. 2022. PMID: 36059274 Free PMC article.
Here, we screened for DUB vulnerabilities in multiple myeloma, an incurable malignancy with dependency on the ubiquitin proteasome system and identified OTUD6B as an oncogene that drives the G1/S-transition. LIN28B, a suppressor of microRNA biogenesis, is specified as a bo …
Here, we screened for DUB vulnerabilities in multiple myeloma, an incurable malignancy with dependency on the ubiquitin proteasome system an …
All-Trans Retinoic Acid Promotes a Tumor Suppressive OTUD6B-beta-TrCP-SNAIL Axis in Esophageal Squamous Cell Carcinoma and Enhances Immunotherapy.
Li L, Zhu R, Zhou H, Cui CP, Yu X, Liu Y, Yin Y, Li Y, Feng R, Katz JP, Zhao Y, Zhang Y, Zhang L, Liu Z. Li L, et al. Adv Sci (Weinh). 2023 Jun;10(16):e2207458. doi: 10.1002/advs.202207458. Epub 2023 Apr 10. Adv Sci (Weinh). 2023. PMID: 37038094 Free PMC article.
Although beta-TrCP stability is known to be mediated by the ubiquitin-proteasome system, it is unclear which enzymes play a major role to determine beta-TrCP stability in the context of ESCC. In this study, OTUD6B is identified as a potent deubiquitinase of beta-TrCP that …
Although beta-TrCP stability is known to be mediated by the ubiquitin-proteasome system, it is unclear which enzymes play a major role to de …
Human OTUD6B positively regulates type I IFN antiviral innate immune responses by deubiquitinating and stabilizing IRF3.
Wang J, Zheng H, Dong C, Xiong S. Wang J, et al. mBio. 2023 Oct 31;14(5):e0033223. doi: 10.1128/mbio.00332-23. Epub 2023 Aug 31. mBio. 2023. PMID: 37650650 Free PMC article.
OTUD6B can stabilize the IRF3 protein level via hydrolyzing (Lys33)-linked polyubiquitin at Lys315. More importantly, mice with OTUD6B overexpression exhibited more resistance to RNA virus infection. ...
OTUD6B can stabilize the IRF3 protein level via hydrolyzing (Lys33)-linked polyubiquitin at Lys315. More importantly, mice with OT …
LncRNA OTUD6B-AS1 overexpression promoted GPX4-mediated ferroptosis to suppress radioresistance in colorectal cancer.
Zhang Z, Ye B, Lin Y, Liu W, Deng J, Ji W. Zhang Z, et al. Clin Transl Oncol. 2023 Nov;25(11):3217-3229. doi: 10.1007/s12094-023-03193-7. Epub 2023 May 15. Clin Transl Oncol. 2023. PMID: 37184781

The subcellular localization of lncRNA OTUD6B-AS1 was tested by the nuclear/cytoplasmic fractionation assay, with RNA immunoprecipitation assay to validate gene interactions. ...Ferroptosis inhibitor attenuated radioresistance (P < 0.01) caused by lncRNA OTUD6B-A

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The subcellular localization of lncRNA OTUD6B-AS1 was tested by the nuclear/cytoplasmic fractionation assay, with RNA immunoprecipita …
An angiogenesis-related lncRNA signature predicts the immune microenvironment and prognosis of breast cancer.
Wang YW, Liu C, Chen YD, Yang B, Chen X, Ma G, Tian YR, Bo X, Zhang K. Wang YW, et al. Aging (Albany NY). 2023 Aug 3;15(15):7616-7636. doi: 10.18632/aging.204930. Epub 2023 Aug 3. Aging (Albany NY). 2023. PMID: 37543427 Free PMC article.
OTUD6B-AS1 promoted breast cancer cell proliferation, wound healing, migration, invasion, and human umbilical vein endothelial cells tube formation. ...Our findings suggest that OTUD6B-AS1 could be a therapeutic target for patients with breast cancer....
OTUD6B-AS1 promoted breast cancer cell proliferation, wound healing, migration, invasion, and human umbilical vein endothelial cells …
OTUD6B-AS1 Might Be a Novel Regulator of Apoptosis in Systemic Sclerosis.
Takata M, Pachera E, Frank-Bertoncelj M, Kozlova A, Jüngel A, Whitfield ML, Assassi S, Calcagni M, de Vries-Bouwstra J, Huizinga TW, Kurreeman F, Kania G, Distler O. Takata M, et al. Front Immunol. 2019 May 17;10:1100. doi: 10.3389/fimmu.2019.01100. eCollection 2019. Front Immunol. 2019. PMID: 31156645 Free PMC article.
Therefore, we aimed to identify key regulators of OTUD6B-AS1 and to analyze the functional relevance of OTUD6B-AS1 in SSc. ...OTUD6B-AS1 knockdown did not affect OTUD6B expression at the mRNA level and protein level. ...
Therefore, we aimed to identify key regulators of OTUD6B-AS1 and to analyze the functional relevance of OTUD6B-AS1 in SSc. ... …
Identification of OTUD6B as a new biomarker for prognosis and immunotherapy by pan-cancer analysis.
Zhao G, Song D, Wu J, Yang S, Shi S, Cui X, Ren H, Zhang B. Zhao G, et al. Front Immunol. 2022 Aug 16;13:955091. doi: 10.3389/fimmu.2022.955091. eCollection 2022. Front Immunol. 2022. PMID: 36052059 Free PMC article.
R package "clusterProfiler" was used for enrichment analysis of OTUD6B. Furthermore, we analyzed the correlation between the expression of OTUD6B, immune infiltration, and immune-related genes. ...OTUD6B may play a part in TIME, which could be applied as a ne …
R package "clusterProfiler" was used for enrichment analysis of OTUD6B. Furthermore, we analyzed the correlation between the expressi …
Loss of OTUD6B Stimulates Angiogenesis and Promotes Diabetic Atherosclerosis.
Wang Z, Zhang L, Li L, Zhou M. Wang Z, et al. Diabetes Metab Syndr Obes. 2022 Sep 28;15:3027-3038. doi: 10.2147/DMSO.S380986. eCollection 2022. Diabetes Metab Syndr Obes. 2022. PMID: 36200061 Free PMC article.
However, the mechanism of its regulation is not understood. OTUD6B regulates cell proliferation, migration, and angiogenesis. ...The silencing of OTUD6B resulted in diabetic atherosclerotic mice plaque instability and increased angiogenesis. ...
However, the mechanism of its regulation is not understood. OTUD6B regulates cell proliferation, migration, and angiogenesis. ...The …
Zebrafish otud6b Negatively Regulates Antiviral Responses by Suppressing K63-Linked Ubiquitination of irf3 and irf7.
Zhou Z, Cai X, Zhu J, Li Z, Yu G, Liu X, Ouyang G, Xiao W. Zhou Z, et al. J Immunol. 2021 Jul 1;207(1):244-256. doi: 10.4049/jimmunol.2000891. Epub 2021 Jun 28. J Immunol. 2021. PMID: 34183367
Ovarian tumor domain-containing 6B (OTUD6B) belongs to the OTU deubiquitylating enzyme family. In this study, we report that zebrafish otud6b is induced upon viral infection, and overexpression of otud6b suppresses cellular antiviral response. Disruption of …
Ovarian tumor domain-containing 6B (OTUD6B) belongs to the OTU deubiquitylating enzyme family. In this study, we report that zebrafis …
50 results